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The Nun Study
https://pubmed.ncbi.nlm.nih.gov/9127971/

The Nun Study is a longitudinal study of aging and Alzheimer's disease that examines the brains of Catholic sisters. The study's findings have helped scientists better understand how Alzheimer's disease and other factors affect the brain and cognitive function.

What the study found

• Brain pathology

  The study found that a combination of Alzheimer's disease and brain infarcts (strokes) is strongly associated with dementia.

• Early cognitive status

  The study found that cognitive limitations in early life can predict the development of Alzheimer's disease and other forms of dementia later in life.

• Exercise

  The study found that exercise can help people retain cognitive abilities as they age.

• Antioxidants

  The study suggests that antioxidants, such as vitamins C and E, may help protect the brain from oxidative stress, which can contribute to Alzheimer's disease.

How the study was conducted

• The study collected data on the sisters' risk factors in early and middle life.
• The sisters underwent annual cognitive and physical function evaluations as they aged.
• After death, the sisters' brains were examined for signs of Alzheimer's disease and other brain pathology.

Why the study is important

• The Nun Study is unique because it includes a large number of brains from people who did not have dementia.
• The study's findings can help scientists develop new ways to prevent and treat Alzheimer's disease.

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